[Abstract]

Lysosomes are functional cell organelles which have antimicrobial and anticancerous activity. Lysosomal enzymes are easily integrated or released when exposed to some stimuli factor such as oxidative and starvation stress in all eukaryotic cells. In this study, in order to verify special function of lysosomes, several conditions, such as treatment chemical and glucose starvation were used to stimulate in vitro function of lysosomes. The antimicrobial and anticancerous activity of lysosomes was enhanced in those stimuli in vitro assay. In addition, lysosomes inhibit bacterial growth in blood when we injected lysosomes into rat model infected with bacteremia. Therefore, increases in endogenous levels of lysosomes may have various applications such as antimicrobial agents and apoptosis-inducing materials for cancer cells and it is very promising to use the organelles to improve in vitro and in vivo functions.