[Abstract]

[Career Path in Pharma Industry]

Will it be academia or business? It really is a big question for deciding career path in science. There is a high demand for scientists with R&D experiences in pharma industry in various functions. Here we will review what kind of career path would be possible for individuals trained and competent in R&D.

[Introduction to CAR-T Therapy and Insights into Multiple Myeloma CAR-Ts]

CAR-T (Chimeric Antigen Receptor T cell) is a game-changing technology in oncology. Its impressive efficacy is unprecedented, especially in hematological malignancies. Here, CAR-T technology history and selected up-to-date CAR-T technologies will be shared. Also, CAR-T in a business point of view (regulations, reimbursement, and manufacturing lead time) will be introduced, with focus on obstacles we are facing to bring CAR-T in Korea. Multiple myeloma is called “an incurable disease”. Even after development of various treatments including proteasome inhibitors, immuno-modulators and antibodies, still the patients will eventually relapse and run out of options for further treatment. Two CAR-T treatments for multiple myeloma was approved by FDA recently. It will be interesting to look at efficacy and safety profiles of these CAR-Ts, as well as their comparison with existing therapies, through retrospective studies.